| Date | Location | Result | |
| 3/1/22 | Livingston, AL | West Ala. 71, Delta St. 58 | Box score |
| 02/26/22 | Huntsville, AL | Alabama Huntsville 75, Delta St. 65 | Box score |
| 2/24/22 | Livingston, AL | West Ala. 76, Delta St. 53 | Box score |
| 02/19/22 | Cleveland, MS | Montevallo 86, Delta St. 70 | Box score |
| 02/17/22 | Cleveland, MS | Auburn Montgomery 61, Delta St. 57 | Box score |
| 02/12/22 | Memphis, TN | Delta St. 87, Christian Brothers 79 (OT) | Box score |
| 02/10/22 | Jackson, TN | Delta St. 58, Union University 55 | Box score |
| 02/05/22 | Clinton, MS | Delta St. 67, Mississippi Col. 63 | Box score |
| 01/31/22 | Cleveland, MS | Lee University 79, Delta St. 64 | Box score |
| 01/05/22 | Carrollton, GA | West Georgia 73, Delta St. 66 | Box score |
| 01/20/22 | Cleveland, MS | Delta St. 97, Shorter University 56 | Box score |
| 01/15/22 | Pensacola, FL | West Florida 94, Delta St. 60 | Box score |
| 01/13/22 | Valdosta, GA | Valdosta State 79, Delta St. 66 | Box score |
| 01/05/22 | Carrollton, GA | West Georgia 73, Delta St. 66 | Box score |
| 01/02/22 | Cleveland, MS | Delta St. 72, Mississippi Col. 66 | Box score |
| 12/20/21 | Cleveland, MS | Union University 85, Delta St. 79 (OT) | Box score |
| 12/18/21 | Cleveland, MS | Delta St. 66, Christian Brothers 59 | Box score |
| 12/14/21 | Montevallo, AL | Montevallo 69, Delta St. 62 | Box score |
| 12/12/21 | Montgomery, AL | Delta St. 78, Auburn Montgomery 67 | Box score |
| 12/04/21 | Cleveland, MS | Delta St. 62, West Ala. 55 | Box score |
| 12/02/21 | Cleveland, MS | Delta St. 84, Alabama Huntsville 83 (OT) | Box score |
| 11/29/21 | Magnolia, AR | Southern Arkansas 82, Delta St. 60 | Box score |
| 11/23/21 | Cleveland, MS | Blue Mountain 61, Delta St. 56 | Box score |
| 11/20/21 | Cleveland, MS | Lane College 65, Delta St. 62 | Box score |
| 11/18/21 | Cleveland, MS | LeMoyne-Owen 89, Delta St. 84 | Box score |
| 11/13/21 | St. Petersburg, FL | Florida Southern 91, Delta St. 56 | Box score |
| 11/12/21 | St. Petersburg, FL | Delta St. 86, Eckerd College 80 (OT) | Box score |